منابع مشابه
Pathogenesis of testicular germ cell tumours.
Human germ cell tumours comprise a heterogeneous group of neoplasms. In the testis, three entities are distinguished, the teratomas-yolk sac tumours of the infantile testis, the seminomas and nonseminomas of adolescents and adults, and the spermatocytic seminomas. Studies on epidemiology, histology, clinical behaviour, and chromosomal constitution of these tumours support the concept of distinc...
متن کاملImaging of testicular germ cell tumours
In testicular germ cell tumour (GCT), imaging plays a central role in assessment of tumour bulk, sites of metastases, monitoring response to therapy, surgical planning and accurate assessment of disease at relapse. The primary modality used for imaging patients with GCT is computed tomography (CT) but plain film radiography, ultrasound, magnetic resonance imaging (MRI) and positron emission tom...
متن کاملL1-CAM is commonly expressed in testicular germ cell tumours.
Germ cell tumors (GCT) are curable cancers, but 10-15% of patients with metastatic disease fail cisplatinbased first-line therapy. While therapeutic options have increased for various other cancers no therapeutic targets have emerged in cisplatin-refractory GCT. L1 cell adhesion molecule (L1-CAM) is commonly expressed in human malignancies and therefore a potential target, however its expressio...
متن کاملClinical and genetic aspects of testicular germ cell tumours
In this paper we review clinical and genetic aspects of testicular germ cell tumours (TGCTs). TGCT is the most common type of malignant disorder in men aged 1540 years. Its incidence has increased sharply in recent years. Fortunately, survival of patients with TGCT has improved enormously, which can chiefly be attributed to the cisplatin-based polychemotherapy that was introduced in the ninetee...
متن کاملRadiotherapy in testicular germ cell tumours – a literature review
Testicular germ cell tumours (GCT) represent about 1-2% of malignant in men. The essential therapeutic option for early-stage GCT is radical orchiectomy (RO), except in situations that require immediate chemotherapy in patients with a massive dissemination and unequivocally elevated levels of tumour markers. Postoperative radiotherapy (PORT) in patients with testicular seminoma in Clinical Stag...
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ژورنال
عنوان ژورنال: Best Practice & Research Clinical Endocrinology & Metabolism
سال: 2010
ISSN: 1521-690X
DOI: 10.1016/j.beem.2010.01.005